Choroid Plexus Volume Change—A Candidate for a New Radiological Marker of MS Progression

(1) Background: Multiple sclerosis (MS) is an auto-immune, chronic, neuroinflammatory, demyelinating disease that affects mainly young patients. This progressive inflammatory process causes the chronic loss of brain tissue and results in a deterioration quality life. To monitor neuroinflammatory activity predict further development disease, it necessary to find suitable biomarker could easily be used. In this research, we verify usability choroid plexus (CP) volume, new MS biomarker, monitoring progression multiple disease. (2) Methods: A single-center, prospective study with three groups patients was conducted based on following groups: who received experimental cellular therapy (Treg), treatment-naïve healthy controls. (3) Results: concludes there correlation between CPV/TIV (choroid plexus/total intracranial volume) ratio progress disease—patients (MS + Treg) had larger volumes plexuses. ratios were constantly significantly growing. Treg group, relapses plexuses comparison group no MS. similar observed for GD+ (patients postcontrast enhancing plaques) compared against non-GD without plaques). (4) Conclusion: Choroid due its immunological function, correlates central nervous system. We consider become valuable radiological activity.